Ling pIL-1 processing by calpain and the release of mature IL-

Ling pIL-1 processing by calpain and the release of mature IL-1. However, Gross et al.137 showed that caspase-1 dependency for IL-1 secretion can differ depending on the stimulus and the targeted inflammasomes and does not seem to require the protease activity of caspase-1. IL-1 secretion may therefore rely on redundant parallel pathways. In fact, elevated intracellular Ca2+ triggers IL-1 secretio

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